嘉陵江香

  • 生物学教授
  • Chair of 生物学 Graduate Affairs Committee

标签:

  1. 首页
  2. Office and Department 目录
  3. 目录
  4. 嘉陵江香

教育

M.D. Xuzhou Medical University
Ph.D. University of Alabama at Birmingham

研究兴趣

The work in my laboratory is focused on answering the basic biological questions at the molecular level related to human diseases. The research areas include program cell death, signaling transduction, cellular protein membrane trafficking. One of the major projects involves proapoptotic Bcl-2 family members, such as Bax and Bad. We identified a unique Bax isoform, which may serve as a prognostic marker for cancer chemotherapy. We also defined a broad signaling interplay between apoptotic pathway and other signaling pathways, involving many pathological events, such as hormone refractory and inflammation. We believe that study of the cellular signaling process will help our understanding of the molecular basis of human diseases and identify cellular targets for the effective treatment.

出版物

  • Yao Q, Zhang H, Zhao Y, Ye Z, Lee YJ, 香珍 (2018). The C-terminus of Ubl4A is critical for pro-death activity and association with the Arp2/3 complex. 物化学 Biophys Res Commun. 2018 Sep 18;503(4):3192-3197. doi: 10.1016/j.bbrc.2018.08.123
  • Chen X, Wang L, Roozbahani GM, Zhang Y, 香珍，关旭(2018). Nanopore label-free detection of single-nucleotide deletion in Baxα/BaxΔ2
  • 电泳. 2018年7月12日. doi: 10.1002 / elp.201800193. [印前Epub]
  • 闫杰，张宏， 香珍, Zhao Y, Yuan X, Sun B, Lin A (2018). The BH3-only protein BAD mediates TNFα cytotoxicity despite concurrent activation of IKK and NF-κB in septic shock. 细胞Res. 2018年7月,28 (7):701 - 718. doi: 10.1038/s41422-018-0041-7
  • Chen X, M Roozbahani G, Ye Z, Zhang Y, Ma R, 香珍，关旭(2018). Label-Free Detection of DNA Mutations by Nanopore Analysis.ACS Appl Mater Interfaces. 2018 Apr 11;10(14):11519-11528. doi: 10.1021 / acsami.7b19774
  • Mañas A, Davis A, Lamerand S, 香珍 (2018). Detection of pro-apoptotic Bax∆2 proteins in the human cerebellum. 组织化学细胞生物学. 2018年7月,150 (1):77 - 82. doi: 10.1007/s00418-018-1669-6
  • Mañas A, Chen W, Nelson A, Yao Q, 香珍 (2018). BaxΔ2 sensitizes colorectal cancer cells to proteasome inhibitor-induced cell death. 物化学 Biophys Res Commun. 2018. 496(1):18-24. DOI: 10.1016/j.bbrc.2017.12.156
  • Mañas A, Wang S, Nelson A, Li J, Zhao Y, Zhang H, Davis A, Xie B, Maltsev N, 香珍 (2017). The functional domains for Bax∆2 aggregate-mediated caspase 8-dependent cell death. Exp 细胞Res. 2017. 359(2):342-355. DOI: 10.1016/j.yexcr.2017.08.016
  • Zhao Y, Zhang H, Affonso C, Bonomo R, Mañas A, 香珍 (2017). Deficiency in ubiquitin-like protein Ubl4A impairs migration of fibroblasts and macrophages. 物化学 Biophys Res Commun. 2017. 483(1):617-623. DOI: 10.1016/j.bbrc.2016.12.094
  • Zhao Y, Lin Y, Zhang H, Mañas A, Tang W, Zhang Y, Wu D, Lin A, 香珍 (2015). Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching. 美国国家科学促进会. 2015. 112(31):9644-9649. PMID: 26195787, PMCID: PMC4534221
  • Zhang H, Tassone C, Lin N, Mañas A, Zhao Y, 香珍 (2015). Detection of Bax Microsatellite Mutations and BaxΔ2 Isoform in Human Buccal 细胞s. [J]细胞科学. 2015. 6(增刊8):002. DOI: 10.4172/2157-7013.S8-002
  • Zhang H, Lin Y, Manas A, Zhao Y, Denning MF, Ma L, 湘,我. (2014) Bax∆2 promotes apoptosis through caspase-8 activation in microsatellite unstable colon cancer. 摩尔. 癌症Res. 12(9), 1225-23.
  • Haferkamp B.张，H.基辛格，S.王欣.，林，Y.舒尔茨，m.s., 湘,我. (2013) BaxΔ2 family alternative splicing salvages Bax microsatellite-frameshift mutations. 基因 & 癌症. 4, 501-512.
  • 燕,我., 湘,我.，林，Y.，妈，J.张，J.张，H.孙，J.纽约州丹尼尔(daniel.刘杰.Lin, A. (2013). Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation. 细胞. 152(1), 304-315.
  • 林,Y.， Lu, Z.科康提斯，J., 湘,我. (2013). Androgen receptor primes prostate cancer cells to apoptosis through down-regulation of basal p21 expression. 物化学. Biophys. Res. Commun. 430(1), 289-93.
  • Haferkamp B.张，H.，林，Y.,对啊. X，弹跳，A.夏普，J., 湘,我. (2012). BaxΔ2 is a novel Bax isoform unique to microsatellite unstable tumors. J. 医学杂志. 化学. 287(41), 34722-9.
  • 戈弗雷,B.，林，Y., 湘,我. (2010). Structure and function analysis of the pro-death domains of androgen receptor in prostate cancer cells. 细胞Res. 20: 1138-1140.
  • Tang F, Kokontis J, Lin Y, Liao S, Lin A, 湘,我. (2009).Androgen via p21 inhibits TNF-alpha-induced JNK activation and apoptosis. J. 医学杂志. 化学. 284(47), 32353-8.
  • 邓,H.， Yu, F.陈杰.赵，Y., 湘,我.Lin, A. (2008). Phosphorylation of bad at Thr201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1. J. 医学杂志. 化学. 283(30):20754-60.
  • 林,Y.福池，J.希帕卡，R.科康提斯，J., 湘,我. Up-regulation of Bcl-2 is required for the progression of prostate cancer cells from androgen-dependent to androgen-independent growth. 细胞Res. 17(6), 531-536 (2007).
  • 林,Y.科康提斯，J.唐，F.，廖，S.Lin, A.陈，C., 湘,我. Androgen and Its Receptor AR Promote BAX-mediated Apoptosis. 摩尔. 细胞. 医学杂志. 26(5), 1908 –1916 (2006).
  • Yu, C.， Minemoto, Y.张，J.刘杰.唐，F.我，我。.Lin, A.*和 湘,我*. Activation of the JNK pathway inhibits IL-3 withdrawal induced apoptosis in B-lymphocytes. 分子细胞. 13, 329-340 (2004).
  • 湘,我., Gomez-Navarro, J, Arafat, W.、刘斌.巴克，S.D.阿尔瓦雷斯，R.D.西格尔·G.P.Curiel, D.T. Pro-apoptotic treatment with an adenovirus encoding bax enhances the effect of chemotherapy in ovarian cancer. J. 基因医学2(2), 97-106 (2000).
  • 湘,我.赵，D.T.科斯迈耶，S.J. Bax-induced cell death may not require interleukin 1 b-converting enzyme-like proteases. Proc. 国家的. 阿德莱德大学. Sci. 美国. 93, 14559-14563 (1996).

专业知识

  • 分子细胞生物学
  • 信号网络
  • 细胞程序性死亡
  • 癌症生物学